超血糖抑制乳酸清除在运动期间在1型糖尿病
Davide Romeres1, Yogesh Yadav1, F N U Ruchi1
1Division of Endocrinology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
高血糖症在运动期间降低了1型糖尿病 (T1D) 患者的乳酸清除,增加了循环中的乳酸水平. 这一发现表明,在血糖高的情况下炼可能会导致T1D患者更早达到乳酸值.
科学领域:
- 运动生理学 运动生理学
- 代谢研究研究 代谢研究
- 糖尿病管理 糖尿病管理
背景情况:
- 循环中的乳酸度是影响运动耐受性的关键因素.
- 了解乳酸代谢对于1型糖尿病 (T1D) 患者至关重要.
研究的目的:
- 研究T1D患者在运动期间高血糖对乳酸代谢的影响.
- 为了在不同的葡萄糖条件下比较T1D和非糖尿病 (ND) 个体之间的乳酸动力学.
主要方法:
- 一项涉及7名T1D和7名ND参与者的比较研究.
- 对于T1D参与者来说,在euglycemic (5.5mM) 和hyperglycemic (9.2mM) 条件下,在65%的最大氧气摄入量 (VO2max) 下进行的运动会.
- [1-13C] 乳酸注入和分析乳酸周转在运动60分钟前,期间和之后.
主要成果:
- 乳酸动力学被模拟使用一个2个隔间系统.
- 循环中的乳酸度在T1D参与者在运动期间在高血糖症下明显高于euglycemia.
- 在T1D患者的高血糖期间,乳酸清除 (CL) 降低,而乳酸外观没有差异.
结论:
- 高血糖症在T1D中通过降低乳酸清除,导致循环乳酸水平升高而损害运动期间的乳酸代谢.
- 在高血糖期间炼可能会导致T1D患者更早达到乳酸值.
- 这些发现对T1D患者的运动管理和T1D的休运动员有重大影响.
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