Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Neural representation of action symbols in primate frontal cortex.

Nature·2026

Same author

Global error signal guides local optimization in mismatch calculation.

Nature communications·2026

Same author

Competitive interactions shape mammalian brain network dynamics and computation.

Nature neuroscience·2026

Same author

A hierarchy of time constants and reliable signal propagation in the marmoset cerebral cortex.

Nature communications·2025

Same author

Correction: Short- and long-term modulation of rat prefrontal cortical activity following single doses of psilocybin.

Molecular psychiatry·2025

Same author

Short- and long-term modulation of rat prefrontal cortical activity following single doses of psilocybin.

Molecular psychiatry·2025

Search research articles

相关实验视频

Updated: Jul 6, 2025

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

细胞类型特定的连接体预测了小鼠大脑中的分布式工作记忆活动.

Xingyu Ding¹, Sean Froudist-Walsh^1,2, Jorge Jaramillo^1,3

¹Center for Neural Science, New York University, New York, United States.

|January 4, 2024

概括

一个新的大规模小鼠大脑模型揭示了工作记忆如何依赖于分布式大脑网络. 细胞类型特定的连接和内部神经元密度决定了大脑如何维护信息,突出了需要详细的连接学.

关键词:

吸引人的吸引力.细胞类型细胞类型计算模型是一种计算模型.连接ome连接ome连接ome 内部神经元内部神经元这是一个大规模的大型.这里是鼠标鼠标鼠标鼠标鼠标鼠标.神经科学神经科学工作记忆工作记忆

更多相关视频

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

相关实验视频

Last Updated: Jul 6, 2025

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

科学领域:

神经科学是一个神经科学.
计算生物学计算生物学
认知科学认知科学

背景情况:

连接学和神经生理学的进步使得全脑机制研究成为可能.
工作记忆对于在没有感官输入的情况下内部保存和处理信息至关重要.

研究的目的:

开发一个大规模的多区域小鼠大脑模型来研究工作记忆.
调查连接组数据和内部神经元密度如何影响工作记忆编码.

主要方法:

使用区域间皮层连接数据构建了小鼠大脑的中视镜模型.
包含了表达帕瓦胺的内部神经元密度的宏观梯度.
分析的细胞类型特定图表测量以预测活动模式和子网络.

主要成果:

工作记忆编码是分布式的,但模块化的,受远程,细胞类型特定向和内部神经元密度的影响.
确定了一个核心子网络,该子网络对于内存维护至关重要.
该模型表现出多个吸引力状态,代表自我维持的内脑状态.

结论:

开发的模型为解释认知任务期间的大规模大脑活动记录提供了一个框架.
强调细胞类型特定连接学在理解大脑功能中的关键作用.
表明分布式但模块化编码,由特定的神经元群体塑造,是工作记忆的基础.