在IGFALS基因中的多态性及其与胡羊羔阴囊周长的关联
Zongwu Ma1, Weimin Wang2, Deyin Zhang2
1College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.
Animal biotechnology
|January 4, 2024
概括
胡羊的阴囊周长高度遗传,并受到IGFALS基因变异的影响. 在IGFALS基因的特定突变可以作为一个分子标记,以改善羊繁殖计划.
科学领域:
- 动物遗传学动物遗传学
- 生殖生物学 生殖生物学
- 基因组选择 基因组选择
背景情况:
- 阴囊周长 (SC) 是雄羊生殖潜力的关键指标.
- SC与精液质量和射精量有遗传相关性,这对育种计划至关重要.
- 了解影响SC的遗传因素对于提高绵羊繁殖效率至关重要.
研究的目的:
- 在胡羊中调查SC的遗传参数.
- 确定与SC相关的胰岛素类生长因子1 (IGF-1) 和IGF结合蛋白基因 (IGFALS) 的遗传变异.
- 探索IGFALS基因多态的潜力,作为Hu羊中SC选择的分子标记.
主要方法:
- 对1353只黄羊的SC测量的描述性统计分析.
- 在不同发育阶段对SC的遗传性估计.
- 通过PCR放大和IGFALS基因的桑格测序来检测多态.
- 确定IGFALS基因突变与SC之间的关联分析.
主要成果:
- 在胡羊群中,SC表现出高遗传性 (0.3180.719) 和显著的变异性 (>10%).
- 在IGFALS基因的第1个特异体中发现了一种同名突变 (g.918G>C).
- 这种IGFALS突变在多个发育阶段 (100180天,p <0.05) 显着与SC相关.
结论:
- 伊格法尔斯基因多态是影响胡羊SC的重要因素.
- 鉴定到的IGFALS突变可以用作用于标记器辅助选择的分子标记物.
- 这项研究为在绵羊养殖中对SC的遗传改进提供了宝贵的参考.
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