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释放氧化的管状聚合体向先进的气体治疗载体发展

Zhezhe Li¹, Suzhen Wang¹, Lili Zhao¹

¹Department of Chemical Engineering, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.

ACS macro letters

|January 4, 2024

概括

研究人员开发了管状聚合体,比球状聚合物更有效地释放氧化 (NO). 这些新的NO释放纳米颗粒显示出增强的抗癌性能,提供了一个有前途的气体治疗输送系统.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
化学工程是化学工程的重要组成部分.

背景情况:

氧化 (NO) 对生理过程至关重要,具有治疗潜力.
储存和输送气体NO用于治疗是具有挑战性的.
现有的基于聚合物的NO释放纳米颗粒大多是球形的.

研究的目的:

开发新的可生物降解的无释放的两类块共聚合物.
研究这些共聚合物的自我组装成管状聚合体.
为了比较管状与球状聚合体的NO释放行为和治疗疗效.

主要方法:

可生物降解的两类块共聚合物的合成 (PEG-PTMC-NF).
同聚合物的自组装成管状和球状聚合物体.
在光照射下NO释放的评估.
在体外对抗癌性能的评估.

主要成果:

从PEG-PTMC-NF共聚合物中成功制备了管状聚合体.
与球形聚合体相比,管状聚合体的NO释放速度明显更快.
从管状聚合体中释放的NO的数量是球形对应物中释放的1.5倍.
与球形聚合体相比,管状聚合体表现出更强的抗癌疗效.

结论:

聚合体形态显著影响NO释放动力学和治疗效果.
管状NO释放聚合体构成了增强气体治疗的高效平台.
这项研究突出了形态控制纳米结构在改善药物输送方面的潜力.

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相关概念视频

Nitric Oxide Signaling Pathway

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...