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伊斯拉特拉维尔迪默:一个辐射诱导的降解产品的晶体形式依赖性

Josey E Topolski1, Alex M Confer1, Mengwei Hu1

  • 1Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Molecular pharmaceutics
|January 4, 2024
PubMed
概括

马辐射导致在伊斯拉特拉维尔的只有一个晶体形式中产生特定的二聚体杂质. 这种取决于晶体形式的降解凸显了固态形式在药物稳定性方面的重要性.

关键词:
降解降解降解降解降解.分化二元化是指二元化的过程.马辐射辐射的马辐射辐射.这是latravir的岛屿.多形态主义多态主义.

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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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