SARS-CoV-2的垂直传播 - 来自德国COVID-19相关产科和新生儿结局研究 (CRONOS) 的数据
Nadine Mand1, Mario Rüdiger2, Matthias Hütten3
1Department of Pediatrics, Philipps University of Marburg, Marburg, Germany.
Journal of perinatal medicine
|January 4, 2024
概括
新生儿SARS-CoV-2感染发生在2.1%的新生儿出生于感染的母亲,严重的母体COVID-19和Delta变种感染的风险增加. 测试新生儿对于识别SARS-CoV-2作为NICU入院的原因至关重要.
科学领域:
- 周围生理学 周围生理学
- 新生儿科学 新生儿科学
- 传染性疾病 传染性疾病
背景情况:
- 周产期的SARS-CoV-2感染对新生儿构成风险.
- 了解传播和结果对于临床管理至关重要.
研究的目的:
- 确定德国感染母亲新生儿的SARS-CoV-2阳性率.
- 确定新生儿SARS-CoV-2感染的危险因素.
- 描述垂直感染新生儿的短期结果.
主要方法:
- 在CRONOS注册表中收集未来数据 (2020年4月至2023年2月).
- 对8540名感染SARS-CoV-2的孕妇进行分析.
- 世卫组织对母婴传播的分类;分析母亲感染严重程度,疫苗接种状态,病毒类型和围产期结果.
主要成果:
- 2.1%的新生儿有证实或可能的SARS-CoV-2感染.
- 严重的母体COVID-19 (OR 4.4) 和Delta变种感染 (OR 3.2) 与新生儿感染有关.
- 感染的新生儿更有可能被录取到NICU (65.2%对27.5%).
结论:
- 在这个德国队列中,新生儿SARS-CoV-2阳性率超过了之前的报道.
- 新生儿SARS-CoV-2感染很罕见,但需要诊断确认.
- 检测SARS-CoV-2-阳性母亲的新生儿是必要的,以确定感染为NICU入院的原因.
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