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Updated: Jul 6, 2025

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与肥胖相关的血CXCL10驱动CX3CR1依赖的巨细胞迁移抑制因子单细胞分泌

Svenja Meyhöfer1,2, Armin Steffen3, Kirstin Plötze-Martin3

  • 1Department of Medicine 1, University Hospital of Schleswig-Holstein, Luebeck, Germany.

ImmunoHorizons
|January 4, 2024
PubMed
概括

肥胖会增加化学基因CXCL10,通过CX3CR1.1影响单细胞功能. 这一途径将与肥胖相关的炎症和免疫反应联系在一起,为疾病机制提供了新的见解.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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