免疫检查点抑制剂:三阴性乳腺癌的新攻击线
Ouissam Al Jarroudi1,2, Khalid El Bairi3,4, Giuseppe Curigliano5,6
1Faculty of Medicine and Pharmacy, Mohammed Ist University, Oujda, Morocco. aljarroudi.ouissam@gmail.com.
Cancer treatment and research
|January 4, 2024
概括
三重阴性乳腺癌 (TNBC) 的预后不好,但针对编程细胞死亡蛋白-1 (PD-1) 的免疫检查点抑制剂 (ICI) 是有前途的. 本综述讨论了TNBC治疗的所有阶段的ICI.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 三重阴性乳腺癌 (TNBC) 由于预后不佳和治疗选择有限,因此具有重大临床挑战.
- 化疗一直是TNBC的主要治疗方式.
- 新兴的免疫疗法,特别是免疫检查点抑制剂 (ICI),正在改变TNBC治疗范式.
研究的目的:
- 提供用于治疗三阴性乳腺癌 (TNBC) 的免疫检查点抑制剂 (ICI) 的全面概述.
- 在TNBC的各个阶段讨论ICI的当前应用和正在进行的调查.
主要方法:
- 对TNBC中ICI的临床试验和已批准的适用情况的审查.
- 分析涉及ICI的新辅助和辅助治疗策略.
- 关于编程细胞死亡蛋白-1 (PD-1) 向疗法的讨论.
主要成果:
- 免疫检查点抑制剂 (ICI),特别是那些向编程细胞死亡蛋白-1 (PD-1) 的免疫检查点抑制剂,已被批准与化疗结合用于表达TNBC的PD-1的第一线治疗.
- 在TNBC患者的新辅助和辅助环境中,ICI正在积极调查中.
- 这些进展为改善TNBC的结果提供了新的治疗途径.
结论:
- 免疫检查点抑制剂在治疗三阴性乳腺癌方面取得了重大进展.
- 在TNBC的各个阶段,ICI的作用正在扩大,提供了更好的治疗选择.
- 进一步的研究将继续完善ICI在TNBC治疗方案中的使用.
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