普鲁卡洛普里德在有或没有上部症状的功能性便秘儿童中的安全性和有效性

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Alejandro Velez¹, Ajay Kaul^1,2, Khalil I El-Chammas^1,2

¹Gastroenterology, Hepatology and Nutrition, Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, Suite T8.382, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.

Paediatric drugs

|January 4, 2024

概括

普鲁卡洛普里德有效治疗儿童的功能性便秘 (FC) 和相关的上部胃肠道症状. 虽然它通常是安全的,但它可能会在一小部分患者中恶化情绪,这些患者有先前存在的情绪障碍.

科学领域:

儿科胃肠病学儿科胃肠病学
药理学药理学是指药理学的学科.

背景情况:

针对胃肠道 (GI) 疾病的普鲁卡洛普里德的儿科研究产生了不一致的结果.
儿童的功能性便秘 (FC) 带来了挑战,通常与上部胃肠道症状同时发生.

研究的目的:

评估普鲁卡洛普里德在被诊断患有功能性便秘的儿科患者的安全性和有效性.
评估普鲁卡洛普里德对上部胃肠道症状和消化障碍同时存在的影响.

主要方法:

一项回顾性分析比较了接受普鲁卡洛普里德和常规疗法的儿科患者与单独接受常规疗法的儿科患者.
患者因年龄,性别,种族和便污染而匹配. 结果包括FC反应,功能上肠道上部症状的解决,消化障碍的改善和不良事件.

主要成果:

在联合治疗组 (70%) 和常规治疗组 (76.6%) 之间没有观察到FC反应的显著差异.
普鲁卡洛普里德在改善功能上部胃肠道症状 (56%) 和消化不良症 (100%) 中表现出显著的疗效.
30%的患者报告了不良反应,主要是腹部. 一小部分 (7%) 患有先前存在的情绪障碍的人经历了情绪恶化,包括两例自杀念头.

结论:

普鲁卡洛普里德是一种有效的治疗同时上部肠道症状和功能性便秘的儿科患者的消化不良.
这种药物在这个人群中通常耐受性很好.
建议小儿科患者因潜在的情绪恶化而有先前存在的情绪障碍.

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