意大利缺甲状腺症的呈现:一个全国性的基于登记册的研究
C Cipriani1, J Pepe2, L Colangelo2
1Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. cristiana.cipriani@gmail.com.
低甲状腺功能障碍症 (HypoPT) 与心血管疾病,癌症和功能衰竭的住院率较高有关,通常是在年轻时. 低血压妇女也显示出感染和认知障碍的风险增加.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 甲状腺功能低下症 (HypoPT) 是一种罕见的内分泌疾病,其特征是甲状腺类激素的产量不足.
- 了解HypoPT的临床表现和相关并发症对于患者管理和公共卫生倡议至关重要.
研究的目的:
- 评估意大利的临床表现和相关的甲状腺功能低下症 (HypoPT) 相关并发症.
- 为了比较HypoPT患者与匹配的对照人群中各种疾病的流行率.
主要方法:
- 一项全国性的研究利用了意大利卫生部2007-2017年医院出院数据.
- 对HypoPT (252.1) 和相关疾病的ICD-9代码进行了分析,不包括部癌症.
- 数据与年龄和性别匹配的非HypoPT对照组进行了比较.
主要成果:
- 与对照人群相比,HypoPT患者因心血管疾病,癌症,功能衰竭,发作,结石,脑和认知障碍而住院的比例显著提高.
- 与心血管疾病,癌症和功能衰竭等相关疾病在HypoPT患者中发生在较年轻的年龄.
- 在HypoPT患者 (0.5%) 的住院死亡率低于对照组 (3.7%).
结论:
- 低甲状腺功能障碍与心血管疾病,癌症和功能衰竭的患病率增加和早期发病有关.
- 发作和结石病是HypoPT.中经常出现的并发症.
- 感染和认知障碍在HypoPT女性中更为普遍.
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