用免疫检查点抑制剂治疗的患者的生存结果:范围审查
Deniz Can Güven1,2,3, Melissa Sy Thong4, Volker Arndt4
1Department of Medical Oncology, Hacettepe University Cancer Institute, 06100 Sihhiye, Ankara, Turkey. denizcguven@hotmail.com.
Journal of cancer survivorship : research and practice
|January 4, 2024
概括
接受免疫检查点抑制剂 (ICI) 治疗的幸存者经常经历显著的毒性,生活质量下降和心理社会问题. 需要对这些癌症患者的长期影响和其他生存结果进行更多的研究.
科学领域:
- 在瘤学瘤学.
- 癌症的生存率 癌症的生存率
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫检查点抑制剂 (ICI) 是现代癌症治疗的基石.
- 接受ICI治疗的患者的生存结果仍未得到充分研究.
- 关于ICI生存率的现实数据对于全面的患者护理至关重要.
研究的目的:
- 进行ICI治疗患者的生存结果的范围审查.
- 评估当前关于ICI幸存者的研究环境.
- 确定ICI治疗后癌症存活率领域的研究缺口.
主要方法:
- 在Web of Science,PubMed和Embase数据库中的系统文献搜索.
- 包括从2010年1月到2022年10月的研究,重点关注现实生活中的队列.
- 对评估ICI治疗患者至少一个生存结果的研究分析.
主要成果:
- 包括39篇论文,重点关注生活质量 (QoL),毒性和心理社会问题.
- ICI治疗与10-15%的3级+免疫相关不良事件 (irAEs) 和20-30%的幸存者的晚期irAEs有关.
- 超过30%的幸存者报告了焦虑/抑郁,30-40%的人经历了神经认知障碍.
结论:
- 用ICI治疗的幸存者在多个幸存者领域面临损伤.
- 显著的毒性负担,较低的QOL和高的心理社会问题率是显而易见的.
- 对于不充分研究的结果,如生育率,财务毒性和返回工作,进一步的研究是必不可少的.
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