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Updated: Jun 15, 2026

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POLE-突变结肠腺癌-病例表现和组织病理学评估

Tamás Pancsa1, Béla Vasas1, Zsombor Melegh2

  • 1Department of Pathology, University of Szeged, Állomás U. 1, Szeged, 6725, Hungary.

Journal of gastrointestinal cancer
|January 4, 2024
PubMed
概括

这项研究强调了一种罕见的POLE突变结肠腺癌,具有多样化的高度形态. 增加的淋巴细胞透和各种瘤模式应该引起对这种亚型的怀疑,有助于诊断和治疗.

关键词:
免疫检查点抑制疗法免疫检查点抑制疗法这是下一代测序.极地突变 极地突变POLE-突变结肠腺癌细胞瘤

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...