益生菌用于预防和治疗困难菌感染
Lorena Valdés-Varela1, Miguel Gueimonde1, Patricia Ruas-Madiedo2
1Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lacteos de Asturias - Consejo Superior de Investigaciones Cientıficas (IPLA-CSIC), Villaviciosa, Asturias, Spain.
益生菌在使用抗生素后恢复肠道健康和预防Clostridium difficile感染 (CDI) 方面表现有前途. 然而,需要更多的标准化临床研究来确认它们的有效性,并确定CDI治疗的最佳菌株.
科学领域:
- 微生物学和肠道健康
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素治疗可以破坏肠道微生物群的平衡,导致失生症.
- 失生症增加了与Clostridium difficile相关的感染 (CDI) 的风险,发病率上升.
- 益生菌被探索为一种抵消抗生素诱导的肠道失调症的策略.
研究的目的:
- 审查益生菌对Clostridium difficile的作用机制.
- 评估目前关于益生菌用于预防或治疗CDI的证据.
- 突出需要进行标准化临床试验,评估CDI的益生菌.
主要方法:
- 审查关于益生菌和Clostridium difficile.现有的文献.
- 在体外研究的分析表明益生菌抑制C. difficile.
- 对CDI的益生菌疗效的现有临床数据的评估.
主要成果:
- 许多益生菌菌株在体外表现出对C. difficile生长和毒素生产的抑制作用.
- 具有强有力的证据的有限的临床研究支持只有少数益生菌的有效性,比如Lactobacillus rhamnosus GG和Saccharomyces boulardii.
- 对C. difficile的益生菌机制的理解正在进步,这表明了治疗潜力.
结论:
- 益生菌是有希望的活生物治疗剂,用于管理CDI.
- 进一步的标准化临床研究对于验证益生菌有效性和确定CDI的最佳候选人至关重要.
- 使用抗生素和益生菌的联合治疗需要严格的评估.
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