Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

3.6K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
3.6K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

166
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
166
Standard Precaution01:26

Standard Precaution

1.9K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
1.9K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

128
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
128
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

123
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
123

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

<i>Clostridioides difficile</i> Immunity During Pregnancy and Passive Antibody Transfer to Neonates from Cord Blood and Breast Milk.

Toxins·2026
Same author

A case report on the design and implementation of a multinational blended intensive programme in clinical pharmacy practice.

Currents in pharmacy teaching & learning·2026
Same author

The state of play of rodent models for the study of <i>Clostridioides difficile</i> infection.

Journal of medical microbiology·2024
Same author

Anti-S-layer monoclonal antibodies impact <i>Clostridioides difficile</i> physiology.

Gut microbes·2024
Same author

Schistosoma haematobium urinary tract complications in African migrants attending primary care facilities in Paris, France: A retrospective cohort study (2004-2018).

Infectious diseases now·2023
Same author

Unraveling Membrane Perturbations Caused by the Bacterial Riboregulator Hfq.

International journal of molecular sciences·2022

相关实验视频

Updated: Jul 6, 2025

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
09:12

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

Published on: June 15, 2018

10.1K

免疫策略对抗困难的闭膜杆菌.

Camille Campidelli1, Jean-François Bruxelle2, Anne Collignon1

  • 1Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.

Advances in experimental medicine and biology
|January 4, 2024
PubMed
概括

新的免疫疗法和疫苗对于对抗复发性Clostridioides difficile感染 (CDI) 至关重要,这是一个严重的公共卫生威胁. 策略的重点是引起宿主免疫力对抗C. difficile毒素和表面蛋白质.

关键词:
这是C. difficile.殖民化的因素被动免疫接种是被动的免疫接种.毒素是一种毒素.疫苗 疫苗是一种疫苗.

更多相关视频

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.0K
Culturing and Maintaining Clostridium difficile in an Anaerobic Environment
11:13

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

38.8K

相关实验视频

Last Updated: Jul 6, 2025

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
09:12

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

Published on: June 15, 2018

10.1K
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.0K
Culturing and Maintaining Clostridium difficile in an Anaerobic Environment
11:13

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

38.8K

科学领域:

  • 免疫学 免疫学 免疫学
  • 传染性疾病 传染性疾病
  • 微生物学 微生物学

背景情况:

  • 由于其高复发率和经济影响,困难杆菌感染 (CDI) 构成了重大公共卫生挑战.
  • 现有的抗生素治疗不够,需要新的预防,治疗和复发减少策略.
  • 对于复发性CDI,建议进行便微生物群移植,但引起宿主免疫力是一种关键的替代方法.

研究的目的:

  • 审查目前针对CDI的被动免疫疗法和疫苗策略.
  • 总结宿主对C. difficile及其毒性因子的免疫反应.
  • 分析免疫接种方法的目标是毒素和表面蛋白质.

主要方法:

  • 关于CDI的被动免疫和疫苗开发的出版文献的综述.
  • 在动物模型和人类临床试验中对免疫检测的分析.
  • 根据抗原 (毒素,表面蛋白) 和施用途径 (肠道,粘膜) 分类策略.

主要成果:

  • 被动免疫策略根据抗原标,抗体产品和施用途径而有所不同.
  • 主动免疫策略利用抗原通过腹腔或粘膜路径向毒素或表面蛋白质.
  • 用动物模型和人体试验进行的研究表明了这些免疫治疗方法的潜力.

结论:

  • 无论是被动免疫还是主动免疫策略,都在预防和治疗CDI及其复发方面表现有前途.
  • 通过各种免疫方法向C. difficile毒素和表面蛋白质是一个可行的治疗途径.
  • 进一步开发免疫疗法和疫苗对于解决CDI持续威胁至关重要.