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与运动协调的乳酸促进了 inguinal 白脂肪组织的棕色化

Xuefei Chen^1,2, Yanjun Li², Jingbo Zhang²

¹School of Physical education (Main campus), Zhengzhou University, Zhengzhou, China.

Journal of physiology and biochemistry

|January 4, 2024

概括

外源乳酸是一种运动代谢物,促进白色脂肪组织色,增加能量消耗. 运动前补充乳酸增加了这些代谢益处,表明其作为一种新的运动辅助剂的潜力.

科学领域:

运动生理学运动生理学
代谢调节代谢调节代谢调节
脂肪组织生物学脂肪组织生物学

背景情况:

乳酸是一种重要的运动代谢物,已知可以通过解蛋白1 (UCP1) 的上调调节来诱导白色脂肪组织 (WAT) 色.
乳酸在部白脂肪组织 (iWAT) 运动诱导的棕色化中的特定作用仍然不完全理解.

研究的目的:

调查慢性运动前乳酸剂给药对能量代谢和iWAT棕色化的影响.
探索乳酸作为一种运动补充剂对代谢调节的潜力.

主要方法:

小鼠接受了慢性运动前的乳酸注射以及不同的运动方案 (MICT,HIIT).
评估血液中的乳酸盐水平,能量消耗 (间接热量计),WAT重量和色标志物的表达 (UCP1,PPARγ,MCT1) 通过西部斑和qRT-PCR.

主要成果:

在中度强度持续训练 (MICT) 之前服用乳酸盐会降低WAT体重与身体体重的比率,并增加能量消耗.
与其他组相比,LAC+MICT组显示iWAT色标记物 (Ucp1,Pparγ) 和单碳酸载体-1 (Mct1) mRNA的表达显著增加.
高强度间歇训练 (HIIT) 对脂肪组织的影响被DCA部分抑制,这表明特定的代谢途径.

结论:

外源乳酸在运动介导的iWAT棕色化中起作用.
潜在的机制包括通过MCT1和/或PPARγ上调调节增强乳酸运输.
研究结果表明外源乳酸可能作为一种新的炼补充剂来调节新陈代谢.

关键词:

运动运动运动.乳酸盐补充剂可以补充.在UCP1中,UCP1是UCP1.白色脂肪组织变棕色

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