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[生育治疗后的儿童癌症?
Mandy Spaan1,2, C B Nils Lambalk3, Floor E van Leeuwen1
1Nederlands Kanker Instituut, afd. Epidemiologie, Amsterdam.
Nederlands tijdschrift voor geneeskunde
|January 4, 2024
概括
辅助生殖技术 (ART) 可能不会增加儿童癌症的总体风险. 然而,在冷解胚胎移植 (FET) 后出生的儿童的潜在风险增加需要进一步的大规模研究.
科学领域:
- 生殖医学 生殖医学
- 儿科瘤学 儿科瘤学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 自1978年以来,已有超过1000万名儿童通过辅助生殖技术 (ART) 出生.
- 在关键的表观遗传编程窗口期间,ART程序与自然受孕有很大的不同.
- 对ART对早期胚胎发育和长期健康的潜在影响,包括癌症风险,需要调查.
研究的目的:
- 评估ART与儿童癌症风险之间的关联.
- 调查潜在的分组差异,例如与冷解胚胎移植 (FET) 相关的差异.
主要方法:
- 在ART后检查儿童癌症发病率的流行病学研究的综述和综述.
- 与癌症风险相关的特定ART技术 (包括FET) 的分析.
主要成果:
- 总的来说,流行病学数据表明,ART与儿童癌症风险增加无关.
- 对于通过FET怀孕的孩子,可能存在潜在的,适度的风险增加,尽管基于有限的病例.
- 目前正在探索FET后风险增加的生物学机制.
结论:
- 目前的证据在很大程度上是令人放心的关于ART和儿童癌症风险.
- 在临床实践发生变化之前,需要进一步进行大规模的队列研究,以确认或驳斥与FET相关的潜在风险.
- 持续的研究对于了解ART的长期健康影响至关重要.
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