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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research
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循环瘤细胞:从基础到翻译研究

Luis Enrique Cortés-Hernández1,2, Zahra Eslami-S2,3,4, Klaus Pantel1,2

  • 1Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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概括
此摘要是机器生成的。

这篇评论强调了循环瘤细胞 (CTC) 作为癌症转移的关键参与者. 了解CTC为精密癌症医学提供了新的诊断和治疗策略.

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科学领域:

  • 在瘤学瘤学.
  • 癌症生物学 癌症生物学
  • 翻译研究是翻译研究.

背景情况:

  • 转移是癌症死亡的主要原因.
  • 研究在很大程度上忽视了血液传播的癌细胞扩散,这是转移的一个关键步骤.
  • 循环瘤细胞 (CTC) 为转移级联提供了一个窗口.

研究的目的:

  • 审查CTC基础和翻译研究的最新进展.
  • 要突出CTCs在转移级联中的作用.

主要方法:

  • 关于CTC的基础,翻译和临床研究的文献综述.
  • 分析与CTC计数和分子调查相关的发现.

主要成果:

  • 对CTC的翻译研究揭示了转移过程的复杂性.
  • CTC 提供了关于癌细胞扩散的宝贵见解.

结论:

  • 了解CTC对于推进癌症研究至关重要.
  • 对CTC的进一步研究可能会导致新的治疗和诊断策略.
  • 准CTC可以为所有癌症患者提供精准医学.