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Updated: Jul 6, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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Published on: August 20, 2019

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TREX2 缺乏抑制了自发性和基因毒素相关的突变发生

Teresa Marple1, Mi Young Son2, Xiaodong Cheng3

  • 1Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA.

Cell reports
|January 4, 2024
PubMed
概括

修复DNA酶TREX2显著促进缺乏不匹配修复 (MMR) 的细胞中的自发突变. 删除TREX2减少了DNA损伤引起的突变,突出显示了它在基因组稳定中的作用.

关键词:
科普:分子生物学 分子生物学耐受性 耐受性 耐受性 DNA 损伤这就是TREX2的特点.不匹配的维修 维修不匹配的维修复制叉维护维护复制叉维护维护

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