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在脑血管发育过程中,通过血液流动对细胞细胞增殖的皮埃佐1依赖调节

Huaxing Zi¹, Xiaolan Peng², Jianbin Cao³

¹Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; University of Chinese Academy of Sciences, 19A Yu-Quan Road, Beijing 100049, China.

|January 4, 2024

概括

血液流动通过激活内皮细胞中的Piezo1通道来刺激大脑细胞周细胞的发育,然后通过Notch通道发出信号. 这揭示了血液动力学在脑血管生长中的新作用.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
心血管研究研究心血管研究

背景情况:

血流通过内皮细胞 (ECs) 影响大脑血管发育.
大脑周细胞对于神经血管单元的功能至关重要,包括血脑屏障的完整性.
血液流动对大脑细胞周细胞发育的影响尚不清楚.

研究的目的:

为了调查血液流动是否影响大脑细胞周细胞的发育.
阐明血流可能影响细胞周细胞的分子机制.

主要方法:

在斑马鱼幼虫的体内时间延迟成像.
对信号通路的药理和遗传操纵.
监测细胞周细胞的增殖和脑血管的覆盖.

主要成果:

血液流动促进大脑细胞周细胞的增殖和血管覆盖.
这种效应由EC中的Piezo1通道介导.
在Piezo1的下游,EC内在的Notch信号会激活细胞周围的Notch信号.

结论:

血液流动在大脑细胞周细胞发育中起着重要作用.
该途径涉及EC Piezo1和Notch信号,将血动力学与细胞周围细胞扩张联系起来.
这扩大了我们对血流如何塑造脑血管结构的理解.

关键词:

CP: 发育生物学口信号传输是没有的.这是一个Piezo1.血液的流动,血液的流动.大脑血管系统的大脑血管系统细胞周围细胞.斑马鱼是一种斑马鱼.

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