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脂质形状和包装是pH敏感的mRNA脂质纳米粒子最佳设计的关键

Giulio Tesei1,2, Ya-Wen Hsiao3, Aleksandra Dabkowska4

  • 1Structural Biology and NMR Laboratory & The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen DK-2200, Denmark.

Proceedings of the National Academy of Sciences of the United States of America
|January 4, 2024
PubMed
概括

为RNA输送优化可离子化脂质需要了解它们的pH依赖性行为. 这项研究结合了模拟和实验,以解释脂质特性和RNA如何影响内体逃生,以有效地输送药物.

关键词:
的RNA封装方式.脂质离子化 脂质离子化脂质纳米颗粒是一种纳米粒子.控制pH释放的pH值可以控制.

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