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相关概念视频

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

824
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
824
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Vaccinations01:51

Vaccinations

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Overview
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
498
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

990
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
990
Immunological Memory01:23

Immunological Memory

622
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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相关实验视频

Updated: Jul 6, 2025

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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通过抗原输送恢复耐受性

Bana Jabri1,2,3,4, Valérie Abadie1,2,3

  • 1Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Department of Medicine, Chicago, IL, USA.

Science (New York, N.Y.)
|January 4, 2024
PubMed
概括

通过精确传递抗原来控制自身免疫性疾病的新策略正在开发中. 这种方法旨在重新训练免疫系统并逆转有害的自身免疫反应.

科学领域:

  • 免疫学
  • 自身免疫性疾病
  • 治疗策略

背景情况:

  • 自身免疫性疾病是免疫系统对身体自身组织的攻击.
  • 目前的治疗方法通常会大大抑制免疫系统,
  • 调节抗原输送提供了一种有针对性的方法来恢复免疫耐受性.

研究的目的:

  • 在自身免疫疾病中研究抗原输送的新方法.
  • 评估抗原调节的潜力,以逆转已建立的自身免疫.
  • 探索针对性抗原传递可以重新培养免疫反应的机制.

主要方法:

  • 开发用于控制特定抗原的方法.
  • 在临床前的自身免疫模型中测试这些策略.
  • 在治疗后评估免疫细胞反应和疾病标志物.

主要成果:

  • 证明成功调节抗原传递到向免疫细胞.
  • 在实验模型中观察到自身免疫病理的逆转.
  • 被抗原调节影响的特定免疫路径.

结论:

  • 抗原输送调节是一种有前途的治疗方法.

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  • 有针对性的抗原输送可以诱导免疫耐受性和逆转自身免疫性.
  • 需要进一步的研究将这些发现转化为临床应用.