通过操纵灵长类的中前线电路来平衡风险回报决策
Ryo Sasaki1, Yasumi Ohta2, Hirotaka Onoe3
1Division of Physiology and Neurobiology, Department of Neuroscience, Graduate School of Medicine, Kyoto University, Kyoto-shi, Kyoto 606-8501, Japan.
概括
这项研究揭示了腹膜区域 (VTA) 如何影响决策中的风险承担. 对6V区域的VTA信号控制了高风险,高回报选择和低风险,低回报选择之间的平衡.
科学领域:
- 神经科学
- 决策研究
- 行为经济学
背景情况:
- 决策涉及固有的风险,在博障碍中看到的病态风险承担.
- 了解风险评估的神经机制对于解决行为病理至关重要.
研究的目的:
- 调查腹部布罗德曼区域6 (区域6V) 的作用及其来自腹部体区域 (VTA) 的输入,以调节风险相关的决策.
- 确定特定的VTA到区域6V路径如何影响高风险,高回报 (HH) 和低风险,低回报 (LL) 的选择.
主要方法:
- 在中使用高风险高回报 (HH) 与低风险低回报 (LL) 选择任务.
- 使用可逆性药物失活6V区域.
- 使用选择性光遗传激活VTA投射到6V区域的腹部和背部方面.
- 应用计算解码来分析行为调节.
主要成果:
- 6V区域的停用削弱了决策对风险的依赖.
- 激活VTA通道到6V区域的腹部方面增加了对HH选择的偏好.
- 激活VTA通道到6V区域的背面增加了对LL选择的偏好.
- 计算机解码成功捕获了这些行为偏好转变.
结论:
- 对于寻求高风险,高回报和低风险,低回报选项之间的平衡,向6V区域输入的VTA非常重要.
- 这种途径为理解和潜在调节冒险行为提供了神经基础.
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