多电解质刷带有类似蛋白质的纳米聚合物
Tatiana O Popova1,2, Oleg V Borisov1,2,3, Ekaterina B Zhulina2
1ITMO University, 197101 St. Petersburg, Russia.
Langmuir : the ACS journal of surfaces and colloids
|January 4, 2024
概括
静电相互作用可以将聚性纳米粒子驱动到具有类似电荷的多电解质刷中. 这是由于纳米粒子电离的变化而发生的,但电荷逆转是必要的,不足以吸收.
科学领域:
- 合体和表面科学科学
- 物理化学 物理化学
- 生物物理学的生物物理.
背景情况:
- 聚性纳米聚合物颗粒 (NP) 模仿球状蛋白质,并与多电解质刷相互作用.
- 了解这些静电相互作用对于控制复杂系统中的NP行为至关重要.
研究的目的:
- 使用理论模型分析解性NP和多电解质刷之间的静电相互作用.
- 调查驱动多电解质刷吸收NP的条件和机制.
主要方法:
- 平均场Poisson-Boltzmann近似被用来建模静电相互作用.
- 分析自由能景观,以确定热力学稳定性和动力学障碍.
主要成果:
- 即使NP和刷具有相同的净电荷标志,也可以出现NP吸收的静电驱动力.
- 这种力源于NP表面弱阴离子和阴离子群的电离状态的变化.
- 插入刷子后的NP电荷逆转是吸收的必要但不足的条件,动力障碍发挥着重要作用.
结论:
- 与缓冲 pH 的异电点 (IEP) 偏差不是 NP 插入自由能量的唯一决定因素.
- 诸如NP组组成,电离常数和盐度等因素显著影响NP-刷相互作用.
- 一个自由能量屏障可以在动力学上阻碍NP吸收,即使在热力学上是有利的,突出了NP吸收的复杂性.
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