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黑色素通过SIRT1/FXR信号轴降低胆酸水平,缓解死性肠球炎

Jiahao Lai¹, Fei Li², Hongfu Li³

¹Department of Pediatrics, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China.

International immunopharmacology

|January 4, 2024

概括

黑色素治疗有效降低胆汁酸 (BA) 水平在一个老鼠模型的死角性肠球炎 (NEC). 这通过SIRT1/FXR通路调节BA载体来实现,减轻肠道损伤,并为NEC提供了有前途的治疗策略.

科学领域:

胃肠病学胃肠病学
分子生物学分子生物学
儿科医学儿科医学

背景情况:

胆汁酸 (BAs) 越来越多地与死性肠球炎 (NEC) 的严重程度有关.
黑素在NEC的治疗作用,可能是通过BA调节,尚未完全理解.

研究的目的:

研究BA在NEC中的作用和黑激素对BA代谢的影响.
阐明黑素对NEC中BA的作用背后的分子机制.

主要方法:

来自NEC患者的肠道组织的转录组分析和小鼠模型.
用单独或用SIRT1调节剂治疗NEC小鼠的黑激素.
评估便/血清BA水平,BA载体表达和肠道损伤.

主要成果:

NEC与失调的BA代谢和BA载体的改变表达有关.
黑色素恢复了异常的BA载体表达 (ASBT,IBABP,OST-α) 通过上调SIRT1和减少FXR乙化.
在小鼠中,黑色素治疗降低了血清/便BA水平,并减轻了NEC的严重程度.

结论:

黑色素通过SIRT1/FXR信号轴降低NEC中的BA水平.
黑色素通过向BA失调,显示出作为NEC治疗剂的潜力.

关键词:

胆汁酸胆汁酸是一种黑色素是什么黑色素是什么黑色素是什么死性肠道结肠炎 (NECO) 是一种

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