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相关概念视频

Phase Transitions: Melting and Freezing02:39

Phase Transitions: Melting and Freezing

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Heating a crystalline solid increases the average energy of its atoms, molecules, or ions, and the solid gets hotter. At some point, the added energy becomes large enough to partially overcome the forces holding the molecules or ions of the solid in their fixed positions, and the solid begins the process of transitioning to the liquid state or melting. At this point, the temperature of the solid stops rising, despite the continual input of heat, and it remains constant until all of the solid is...
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Colloids and Suspensions01:17

Colloids and Suspensions

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
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Phase Transitions: Sublimation and Deposition02:33

Phase Transitions: Sublimation and Deposition

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Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Membrane Fluidity01:26

Membrane Fluidity

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Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
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相关实验视频

Updated: Jul 6, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
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Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

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在细胞集体中拉动固态到液态相变的绳索.

Diana Pinheiro1, Jennifer Mitchel2

  • 1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, 1030, Austria.

Current opinion in cell biology
|January 4, 2024
PubMed
概括

活体组织在固体和流体状态之间进行过渡,但推动这些变化的生物信号尚不清楚. 这种观点突出了有关调节组织类风湿学和集体细胞行为的分子机制的新兴证据.

科学领域:

  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.
  • 组织动态 组织动态

背景情况:

  • 表皮组织必须适应不同的生物环境,从维持恒常状态到在发育过程中进行重塑,伤口愈合和癌症入侵.
  • 在细胞集体中观察到固态和液态之间的过渡,类似于惰性材料,但基本的生物控制机制尚不清楚.

研究的目的:

  • 探索对生物信号的新兴证据,这些信号调节了活组织的集体状态.
  • 强调这些信号机制如何在各种生物环境中被用于功能性适应.

主要方法:

  • 这种观点综合了当前的研究和新发现.
  • 它的重点是识别上游信号通路和分子效应器.

主要成果:

  • 这项研究强调了关键的生物信号,这些信号决定了组织的集体物理特性.
  • 它讨论了这些信号是如何控制组织质学和组织动态的.

结论:

  • 了解组织类风病的生物控制对于理解健康和疾病中的组织功能至关重要.
  • 新出现的证据表明,特定的信号通路是集体细胞行为和组织状态转变的关键调节者.

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