跨交替电流刺激治疗慢性失眠的有效性和年龄对其有效性的影响:一个多站点随机,双盲,并行组,安慰剂控制的多站点随机研究
Xiaolin Zhu1, Yanping Ren2, Shuping Tan1
1Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, 100096, China.
Journal of psychiatric research
|January 4, 2024
概括
超交替电流刺激 (tACS) 有效地治疗成年人的慢性失眠,改善睡眠质量和效率. 老年人显示,这种非侵入性干预特别有显著的益处.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 医疗器械 医疗器械
背景情况:
- 失眠是一种普遍的睡眠障碍,与许多系统性健康问题有关.
- 超交替电流刺激 (tACS) 是一种非侵入性神经调节技术,用于治疗失眠.
- 对于慢性失眠的tACS的精确疗效和潜在机制需要进一步研究.
研究的目的:
- 评估tACS在治疗成年患者慢性失眠的有效性.
- 为了确定患者的年龄如何影响对失眠的tACS治疗反应.
- 用一个大,多中心的样本进行稳健的统计分析.
主要方法:
- 120名患有慢性失眠症的参与者每天接受20次40分钟的活性tACS (77.5Hz,15mA) 或假刺激.
- 在4周的时间里,刺激的目标是额头和乳腺区域.
- 睡眠参数,日常干扰,情绪和临床印象在基线,治疗后和4周随访时被评估.
主要成果:
- 与假装组相比,tACS组在睡眠质量,效率,总睡眠时间和日常干扰方面显著改善 (p < 0.01).
- tACS显著改善了整体临床印象 (p < 0.001),但没有改善抑郁症或焦虑症得分.
- 年龄较大的参与者在睡眠质量,效率和失眠减少方面表现出更强的益处,在随访期间持续存在 (p < 0.001).
结论:
- 跨交替电流刺激 (tACS) 在8周的治疗窗口内为慢性失眠提供了一个可行的治疗选择.
- 年龄是调节tACS在改善失眠症状方面的有效性的重要因素.
- 虽然没有直接影响情绪得分,但tACS诱导的睡眠改善与抑郁和焦虑症状的减少相关.
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