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Updated: Jul 6, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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合成和抗瘤活动的循环坦合的 antraquinone 衍生物

Alexander S Tikhomirov1, Yuri B Sinkevich2, Lyubov G Dezhenkova1

  • 1Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, 119021, Russian Federation.

European journal of medicinal chemistry
|January 4, 2024
PubMed
概括

与循环二氨基胺的新型 antracycline 类似物对抗多药耐药瘤表现出强大的抗癌活性. 这些化合物增强细胞吸收并向溶酶体,为克服药物耐药性提供了一个有希望的策略.

关键词:
人类循环类药物.人类氨酸 (Anthraquinone) 是一种它具有抗瘤活性.碳循环化过程中的碳循环化.细胞吸收的时间结合 DNA 的 DNA 结合.德克索鲁比辛是一种多克索鲁比辛.脂友性 脂友性 脂友性Lysosomes 是一个溶解体.这是一种P-glycoprotein蛋白.拓二醇酶 1 的作用.

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