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在反兴奋剂样本中碳氧-Δ8-四大麻醇的流行率

Vinod S Nair¹, Mari Heybroek¹, Emily Boyle¹

¹Sports Medicine Research and Testing Laboratory, South Jordan, Utah, USA.

Drug testing and analysis

|January 4, 2024

概括

合成的delta-8THC (Δ8-THC) 产品在运动员中越来越多地被检测到. 大约12%的分析的运动员样本显示了Δ8-THC-COOH的存在,使药物测试和反兴奋剂工作复杂化.

科学领域:

法医毒理学法医毒理学
分析化学分析化学
运动科学运动科学运动科学

背景情况:

德尔塔-9四大麻 (Δ9-THC) 是大麻中主要的精神活性化合物.
合成的delta-8四大麻 (Δ8-THC) 产品越来越普遍,由于有限的监管和潜在的不良事件,这带来了挑战.
许多体育组织和工作场所的药物测试计划禁止使用大麻素.

研究的目的:

为了估计运动员社区中 Δ8-THC 使用的流行率.
为了监测反兴奋剂样本中 Δ8-THC-COOH 的存在.
为了解决从D8-THC检测中产生的分析和法律复杂性.

主要方法:

开发和利用高性能液体染色体协同质谱法 (LC-MS/MS) 方法.
该LC-MS/MS方法的设计是为了分辨和量化 Δ8-THC-COOH 和 Δ9-THC-COOH 异构体.
对1000个运动员尿液样本的分析,假定 Δ9-THC-COOH 的阳性结果.

主要成果:

大约12%的分析样本检测出 Δ8-THC-COOH.COOH 的存在.
检测到的 Δ8-THC-COOH 含量在阳性样本中占碳氧-THC 总含量的 5% 至 100% 之间.
这些发现凸显了运动员群体中 Δ8-THC 的显著存在.

结论:

该研究证实了运动员中 Δ8-THC 使用的普遍性,其代谢物的检测表明了这一点.
8-THC-COOH与9-THC-COOH的同时存在需要先进的分析技术来准确识别和量化.
需要进一步的研究,以了解D8-THC在体育中的使用的全部影响,并澄清其法律地位.

关键词:

合成大麻素是一种合成大麻素.Δ8 -THCC是什么意思 Δ9-THCC是什么意思

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