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由NIR触发的基于细菌纤维素的伤口包裹用于感染伤口的多重协同治疗

Meiyan Sun¹, Dongmei Li¹, Yan Xi¹

¹State Key Laboratory of Food Nutrition & Safety, Tianjin University of Science and Technology, Tianjin, PR China; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, PR China.

International journal of biological macromolecules

|January 4, 2024

概括

这项研究开发了先进的细菌纤维素 (BC) 伤口用硫化铜纳米颗粒 (CuS NPs) 和多多巴胺 (PDA) 的伤口包裹. 这些敷料表现出增强的抗菌和血管新生特性,加速皮肤伤口愈合.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
再生医学是一种再生医学.

背景情况:

细菌感染和不良的血管形成阻碍了皮肤伤口的愈合.
需要先进的伤口包裹来对抗感染并促进组织再生.
细菌纤维素 (BC) 为伤口愈合应用提供了一个有前途的支架.

研究的目的:

开发一种基于细菌纤维素 (BC) 的多功能伤口敷料.
增强抗菌和血管新生能力,改善伤口愈合.
为了研究BC/多多巴胺 (PDA) /硫化铜纳米颗粒 (CuS NPs) 复合膜的有效性.

主要方法:

制造具有PDA涂层和CuS NP功能的BC基料.
在808nm激光照射下对光热和光动力学活动的评估.
对抗黄金葡萄球菌和大肠杆菌的协同抗菌活性的评估.
在体内对全厚皮肤缺陷的研究,以评估伤口关闭,炎症,原沉积和血管化.

主要成果:

该BC/PDA/CuS复合膜显示可调节的光热和光动力学活动.
在近红外 (NIR) 辐射下,协同抗菌效率达到S. aureus的99.7%,E. coli的88.0%.
复合膜通过受控的Cu2+释放促进了血管生成.
在体内实验表明,加速伤口关闭,减少炎症,增强原沉积,促进血管化.

结论:

开发的BC/PDA/CuS复合膜是一种具有显著抗菌和血管新生功能的多功能伤口敷料.
这种带通过减少炎症,促进原沉积和在NIR辐射下增强血管化来加速皮肤伤口愈合.
该BC/PDA/CuS复合膜具有很高的生物相容性和生物安全性,为临床伤口愈合提供了一种新的策略.

关键词:

血管新生的产生.具有抗菌活性,具有抗菌活性.细菌纤维素的细菌纤维素.

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