用纳米封装精油填充的基托桑基膜:物理化学特征和增强的伤口愈合活性
Adriana de Oliveira E Silva Guerrero1, Talita Nascimento da Silva2, Stephani Araujo Cardoso3
1Laboratório de Proliferação e Diferenciação Celular, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro (UFRJ), Avenida Carlos Chagas Filho, 373, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ CEP 21941-902, Brazil.
International journal of biological macromolecules
|January 4, 2024
概括
这项研究开发出稳定的SFO载荷纳米乳液 (NE),可显著增强小鼠的伤口关闭. 将这些NE纳入奇多:聚乙醇 (PVA) 薄膜中,创造了具有改进性质的有希望的伤口愈合配方.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 慢性伤口带来了重大的经济和临床挑战.
- 由于生物分子的多活性特性,正在探索用于伤口愈合的自然疗法.
- 酸盐是由于其静血,抗微生物和免疫调节作用而成为治疗伤口的有希望的生物材料.
研究的目的:
- 开发和描述用于伤口愈合的SFO装载纳米乳液 (NE).
- 在小鼠模型中评估SFO装载NE的伤口愈合效果.
- 将SFO装载的NE纳入酸盐:聚乙烯醇 (PVA) 薄膜中,并评估其用于伤口应用的特性.
主要方法:
- 用SFO装载的纳米乳液 (NE) 用动态光散射 (DLS) 产生和表征.
- 通过向小鼠施加SFO载荷的NE并测量伤口关闭效率来评估伤口愈合.
- 用SFO加载的NE被纳入酸盐:PVA薄膜中,并使用接触角度,FTIR,TGA和XRD分析了它们的物理,化学和热性能.
主要成果:
- DLS证实了稳定的SFO载荷NE,滴粒大小为~21nm,多分散度指数为0.159.
- 与对照组相比,使用SFO的NE显著提高了小鼠的伤口闭合效率 (p < 0.05).
- 含有SFO载荷NE的基托:PVA薄膜表现出增加的脂性,降低的吸收湿度,以及改变的热特性,表明成功的整合和潜在的伤口愈合.
结论:
- 装有SFO的NE显示出促进伤口愈合的显著治疗性质.
- 含有SFO载荷NE的PVA薄膜是用于伤口愈合的有效配方.
- 开发的配方为治疗慢性伤口提供了一个有希望的天然替代品.
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