在语境可卡因记忆再巩固中,背面拉菲的必要作用
J L Ritchie1, S Qi1, R J Christian1
1Department of Integrative Physiology and Neuroscience, Washington State University College of Veterinary Medicine, Pullman, WA, USA.
Neuropharmacology
|January 4, 2024
概括
背脊拉菲核 (DRN) 对于重新巩固可卡因记忆至关重要,因为在记忆重新激活后立即阻止其活动会减少老鼠寻找毒品的行为.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 成研究 研究成研究
背景情况:
- 记忆再巩固稳定了记忆,影响了持续寻找药物的行为.
- 在药物记忆再巩固中,背脊拉菲核 (DRN) 的作用仍然不清楚.
研究的目的:
- 调查背脊拉菲核在可卡因记忆再巩固中的参与.
- 确定DRN是否对于维持可卡因相关记忆的强度至关重要.
主要方法:
- 鼠被训练在可卡因的自我管理,其次是灭绝和记忆的重新激活.
- 在DRN中测量了神经元激活,使用c-Fos表达.
- 在重新激活后的不同时间点使用巴克洛芬和肌肉醇 (BM) 输注来功能性地禁用DRN.
主要成果:
- 记忆的重新激活增加了DRN中的神经元激活,而不是中间的RAPH核.
- 在重新激活后,即时的DRN内BM输注显著减少了寻找可卡因的行为.
- 在重新激活6小时后禁用DRN或准周水道灰色 (PAG) 并没有影响行为.
结论:
- 背脊拉菲核 (DRN) 对于重新巩固与可卡因相关的记忆至关重要.
- DRN的作用是时间依赖的,特别是在记忆重新激活后立即要求的.
- 这些发现凸显了DRN作为成治疗的潜在治疗点.
关键词:
巴克洛芬是一种这是可卡因可卡因.记忆再巩固的方法马斯基摩尔 (Muscimol) 是一个肌肉分子.拉菲 (Raphae) 拉菲 (Raphae) 的意思是说拉菲 (Raphae) 的意思.c-的使用.更多相关视频
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