长期暴露于PM2.5和早期出现的糖尿病:BMI是否与这种风险有关?
Yalan Li1, Jingjing Wu1, Haibo Tang2
1Health Management Center, The Third Xiangya Hospital, Central South University, Changsha, China; Clinical Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
The Science of the total environment
|January 4, 2024
概括
长期暴露于细颗粒物 (PM2.5) 显著增加患早期糖尿病的风险. 身体质量指数 (BMI) 部分调解了这种关系,强调了对污染控制和体重管理的需要.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 代谢疾病 代谢疾病
背景情况:
- 关于高细颗粒物 (PM2.5) 污染和早期糖尿病之间的联系的研究有限.
- 这种关联背后的代谢机制仍然不清楚.
研究的目的:
- 评估中国高污染地区累积PM2.5暴露与糖尿病 (包括早期发病形式) 之间的关联.
- 探索代谢因素 (如BMI) 作为这种关系中的潜在调解者的作用.
主要方法:
- 从2005年到2021年,在中国湖南省对124,204名成年人的队列进行了跟踪.
- 使用高质量的地面数据估计了PM2.5暴露.
- 考克斯的比例危险模型和调解分析被用来评估关联和调解角色.
主要成果:
- 累积PM2.5每增加1μg/m3都与PM2.5>50μg/m3的地区糖尿病发病率更高 (HR 1.177) 有关.
- 暴露于PM2.5显示出与糖尿病的非线性剂量反应关系,并增加了早期糖尿病的风险.
- 年轻人,男性和BMI较低 (<24 kg/m2) 的人更容易受到影响;BMI变化介导了PM2.5-糖尿病联系的31.06%.
结论:
- 长期暴露于PM2.5会增加患早期糖尿病的风险,而BMI在其中发挥着部分调解作用.
- 建议包括持续控制空气污染,优先考虑弱势群体,有效管理BMI以减轻糖尿病负担.
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