前史似乎不是患有全身性硬化症的女性血管表型的危险因素
Claire De Moreuil1,2, Elizabeth Diot3, Christian Agard4,5
1Internal Medicine, Vascular Medicine and Pneumology Department, Brest University Hospital, Brest, France claire.demoreuil@chu-brest.fr.
RMD open
|January 4, 2024
概括
孕前史与患有全身性硬化症 (SSc) 的女性的血管表型无关. 然而,较高的皮肤分数和较长的疾病持续时间被确定为SSc患者血管并发症的危险因素.
科学领域:
- 类风湿病学 类风湿病学
- 产科 产科 产科 产科 产科
- 血管医学 血管医学
背景情况:
- 系统性硬化症 (SSc) 的血管表型与预后不佳有关.
- 确定SSc血管并发症的危险因素对于早期检测至关重要.
研究的目的:
- 调查SSc.中血管表型的风险因素.
- 具体来说,要确定是否有先兆子史与SSc.中的血管并发症有关.
主要方法:
- 一项观察性多中心病例控制研究,涉及378名患有SSc.的女性.
- 通过问卷和医生填写的关于病史,妊娠史 (包括妊娠前) 和SSc并发症的表格收集的数据.
- 由特定血管并发症定义的病例;对照组与没有这些并发症的SSc患者匹配.
主要成果:
- 在SSc (OR=0.96,95% CI 0.28~3.34,p=0.9) 中,患有先兆子的病史与血管表型无关.
- 较高的罗丹皮肤评分和5年或更长的疾病持续时间被确定为SSc.血管表型的显著风险因素.
结论:
- 在患有SSc和相关怀孕史的妇女中,先兆子并不是发展血管表型的危险因素.
- 疾病持续时间和皮肤干扰严重程度是SSc.血管并发症的关键指标.
相关概念视频
Disorders of the Female Reproductive System
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease IV: Preventive Measures
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Varicose Veins I: Introduction
Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...


