慢性腹腔大动脉封闭性疾病与抗脂综合征相关:一种罕见的呈现
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
RMD open
|January 4, 2024
概括
慢性腹腔大动脉封闭性疾病 (CAAOD) 是抗脂综合征 (APS) 的罕见表现. 吸烟和高homocysteinaemia是CAAOD的aPL阳性患者的关键危险因素,需要早期诊断和管理.
科学领域:
- 血管医学 血管医学
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
背景情况:
- 慢性腹腔大动脉封闭性疾病 (CAAOD) 是抗脂综合征 (APS) 的罕见并发症.
- 抗脂抗体 (aPL) 与动脉和静脉血栓形成有关.
- 在aPL阳性个体中了解CAAOD对于心血管健康和外周循环管理至关重要.
研究的目的:
- 在具有抗脂抗体 (aPL) 患者中研究CAAOD的临床和放射性特征.
- 在aPL阳性患者中识别与CAAOD相关的风险因素.
- 在APS.的背景下,提供关于CAAOD管理的见解.
主要方法:
- 一项病例对照研究,比较aPL阳性患者的CAAOD和非CAAOD动脉血栓事件.
- 从2013年到2021年对临床特征,放射性图像和患者结果的分析.
- 包括114名经历了动脉事件的患者.
主要成果:
- 12名患者被诊断患有腹腔大动脉狭窄或闭塞 (CAAOD).
- 与非CAAOD组相比,CAAOD组的关键吸烟习惯率 (66.67%) 和高homocysteinaemia (66.67%) 显著更高.
- 放射学发现揭示了长段内大动脉狭窄症,有时涉及脏和常见阴道动脉,病变范围从狭窄到完全封闭.
结论:
- 在aPL阳性患者中,CAAOD是一种罕见但显著的表现.
- 吸烟和高homocysteinaemia被确定为CAAOD在这个人群中的关键风险因素.
- 早期诊断和综合管理,包括干预和抗凝药,是强调更好的结果.
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