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在COVID-19疫苗接种后的姿势静止性心力衰竭综合征

Debbie Lin Teodorescu¹, Anxhela Kote¹, Jewel N Reaso¹

¹Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

|January 4, 2024

概括

在COVID-19 mRNA疫苗接种后,姿势静止性心力衰竭综合征 (POTS) 可能发生或恶化. 疫苗接种后患有POTS的患有先前疾病的患者表现出自主功能障碍,但随着治疗改善.

科学领域:

心脏病学心脏病学
神经学神经学
免疫学免疫学免疫学

背景情况:

在COVID-19 mRNA疫苗接种和新的或恶化的姿势正静性心力衰竭综合征 (POTS) 之间存在关联.
了解接种疫苗后的POTS的特征对于患者管理至关重要.

研究的目的:

在接种mRNACOVID-19疫苗后出现新的或恶化的POTS患者的特征.
调查潜在的潜在生理机制和诱导因素.

主要方法:

从POTS诊所报告疫苗接种后症状的患者收集前性数据 (2021年7月至2022年6月).
与健康对照对心率变化 (HRV) 和皮肤交感神经活动 (SKNA) 的比较.
评估先前存在的疾病和临床结果.

主要成果:

十名患者符合纳入标准,所有患者都患有先前存在的疾病 (例如,高移动埃勒斯-丹洛斯综合征,自身免疫性疾病).
与对照组相比,在患者中观察到HRV和SKNA的降低,这表明交感神经系统的改变.
没有发现心肌损伤或心声学异常的证据.

结论:

接种疫苗后的POTS发生在患有先前存在的疾病的患者中,这表明潜在的弱点可能发挥作用.
发现了自主功能障碍,特别是HRV和SKNA的降低.
虽然患者在标准POTS护理下得到改善,但存在复发的风险,特别是在再感染或新的神经并发症时.

关键词:

在 COVID-19 疫情中,慢性静态不耐受症慢性静态不耐受症这是一种失自的自主性.姿势静止性心力衰竭综合征 (postural orthostatic tachycardia syndrome) 是一种表现出静止性心力衰竭的症状.这就是SARS-CoV-2病毒.在 mRNA 疫苗中.

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