对托拉塞米德临床药理动学的系统批判性审查
Abdul Wasay Sherazi1, Ammara Zamir1, Anees Ur Rehman1
1Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
Therapeutic drug monitoring
|January 4, 2024
概括
本次对托拉塞米德 (PK) 药理动学的综述显示,在心力衰竭和脏疾病中药物水平发生变化. 了解这些PK变化有助于临床医生避免不良反应,并为患者优化剂量.
科学领域:
- 药理学和治疗学 药理学和治疗学
- 临床药房 临床药房
- 药物代谢和药理动力学
背景情况:
- 托拉塞米德是一种节循环利尿剂,对于控制充血性心力衰竭,脏疾病和肝脏疾病中的水分保留至关重要.
- 了解托拉塞米德的药理动力学 (PK) 对于安全有效的临床使用至关重要,特别是在有改变生理状态的患者群体中.
研究的目的:
- 系统地审查和整合所有可用的托拉塞米德的药理学数据.
- 在健康个体和患有各种疾病状态的患者中分析torasemide PK.
- 提供数据,帮助临床医生预防药物不良反应,并确定适当的剂量方案.
主要方法:
- 在四个数据库中进行系统的文献搜索.
- 包括21项符合预先定义的资格标准的研究.
- 在PROSPERO (CRD42023390178) 中注册的审查协议.
主要成果:
- 与立即释放配方相比,延长释放托拉塞米德的Cmax较低.
- 与健康人相比,患有充血性心力衰竭的患者在度-时间曲线 (AUC) 下的面积增加了两倍.
- 患有功能衰竭的患者 (清除率<30毫升/分钟) 显示AUC值显著更高 (42.9比8.091毫克每小时-1毫升-1).
- 药物相互作用研究表明,伊尔贝萨坦略微增加了托拉塞米德的AUC,而洛萨坦和恩帕格利夫洛辛没有显著影响.
结论:
- 本综述综合了托拉塞米德的关键药理学参数.
- 这些发现对于治疗脏和肝脏功能障碍患者的药物相互作用有价值.
- 总结的PK数据可以帮助预测多种患者条件的最佳托拉塞米德剂量.
相关概念视频
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