神经刺激治疗:深度大脑刺激,响应性神经刺激和迷走神经刺激
Flavia Venetucci Gouveia1, Nebras M Warsi2, Hrishikesh Suresh2
1Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
概括
耐药性 (DRE) 影响了许多人,但像VNS,DBS和RNS这样的神经刺激提供了新的希望. 这些先进的疗法在减少对传统药物无反应的患者的发作方面表现有前途.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 神经科学是一个神经科学.
背景情况:
- 影响着相当一部分人口,许多人患有耐药性 (DRE).
- 大约三分之一的患者对两种或两种以上的抗药物没有反应,需要替代治疗.
- 神经刺激技术为患有DRE的人提供了潜在的治疗选择.
研究的目的:
- 审查DRE.的迷走神经刺激 (VNS),深度大脑刺激 (DBS) 和响应神经刺激 (RNS) 的指示,优势和局限性.
- 用先进的分析工具总结与和神经刺激相关的神经成像发现.
主要方法:
- 对DRE的VNS,DBS和RNS的当前文献的审查.
- 使用NeuroQuery和NeuroSynth分析神经成像数据,绘制刺激效应和相关的观察结果.
主要成果:
- VNS调节着甲状腺皮质电路,在约50%的患者中减少了发作.
- RNS提供自适应性,闭环刺激,用于发作源于雄辩的皮质.
- DBS针对各种DRE形式,包括Lennox-Gastaut综合征的thalamic核 (前部和中部) 的目标.
结论:
- VNS,DBS和RNS代表了管理DRE的重要治疗方式.
- 这些神经刺激技术为不同的综合征和患者群体提供了量身定制的方法.
- 结合神经成像的进一步研究可以完善这些干预措施的应用和理解.
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