Wnt途径核心压缩剂TLE3与基因素甲基转移酶KMT1A相互作用,以抑制Rhabdomyosarcoma中的分化

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Bhargab Kalita1,2, Subhashni Sahu1, Anushree Bharadwaj1

  • 1Developmental Genetics Laboratory Regional Centre for Biotechnology (RCB) NCR Biotech Science Cluster 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, Haryana, India.

Oncogene
|January 4, 2024
PubMed
概括

核心压缩器TLE3抑制了在拉布多米索尔科马中的Wnt通路. 通过药物治疗准TLE3和KMT1A显示出治疗这种肌肉癌的前景.

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