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Updated: Jul 6, 2025

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玻璃杯细胞应激传感器IRE1β的激活是由粘素伴侣AGR2控制的

Eva Cloots1,2, Phaedra Guilbert1,2, Mathias Provost3,4

  • 1Laboratory for ER stress and Inflammation, VIB Center for Inflammation Research, 9052, Ghent, Belgium.

The EMBO journal
|January 4, 2024
PubMed
概括

陪伴者AGR2通过控制依诺西需要酶-1β (IRE1β) 的活性来调节肠道杯细胞中的未折叠蛋白质反应 (UPR). AGR2 起作用为静脉静止剂,防止自发的 IRE1β 激活,并确保适当的粘素产生.

关键词:
在 AGR2 中,AGR2 是玻璃杯细胞 玻璃杯细胞这就是IRE1ββ.粘液恒常化 粘液恒常化展开的蛋白质反应 (UPR)

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