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走向实用和强大的基于DNA的数据存档,使用阴阳编码系统进行存档
Zhi Ping1,2,3,4, Shihong Chen2,3,5, Guangyu Zhou6,7
1BGI-Shenzhen, Shenzhen, China.
Nature computational science
|January 4, 2024
概括
我们开发了阴阳编码器,一种新的DNA数据存储方法,每核酸编码两位. 这种强大的算法确保了高数据恢复率和与DNA合成和测序技术的兼容性.
科学领域:
- 生物技术是生物技术.
- 生物信息学是一种生物信息学.
- 数据存储数据存储数据存储
背景情况:
- DNA 提供了特殊的耐用性和数据存储密度.
- 现有的DNA数据存储方法在生物相容性和解码精度方面面临挑战.
- 有效的位对基转码对于可靠的DNA数据存储至关重要.
研究的目的:
- 为了引入一个强大的DNA转码算法,阴阳编码器.
- 为了提高与DNA合成和测序的兼容性.
- 为了证明高准确度的数据存储在体外和体内.
主要方法:
- 开发了阴阳编码器,使用两个规则将两个二进制位编码为一个核酸.
- 存储各种文件格式在体外作为藻池和体内作为酵母中的DNA片段.
- 使用测序来评估数据恢复率和存储密度.
主要成果:
- 阴阳编码器在10^4个分子拷贝上实现了99.9%的平均恢复率.
- 在低分子拷贝数 (≤10^2) 的情况下,获得了87.53%的恢复率.
- 在体内储存中,物理密度接近理论最大值.
结论:
- 阴阳编码器为DNA数据存储提供了强大而可靠的解决方案.
- 这种方法显著提高了与当前DNA技术的兼容性.
- 已证明在体外和体内成功存储高保真度的数据.
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