评估营养学随机对照试验和队列研究的证据之间的一致性:一项超级研究复制研究
Julia Stadelmaier1, Jessica Beyerbach2, Isabelle Roux2
1Institute for Evidence in Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. julia.stadelmaier@uniklinik-freiburg.de.
European journal of epidemiology
|January 4, 2024
概括
这项研究发现,随机对照试验 (RCT) 和队列研究通常同意营养证据综合效应估计. 意见分歧往往源于人口,干预,比较和结果 (PI / ECO) 细节的差异.
科学领域:
- 营养科学 营养科学
- 超级研究的研究.
- 证据综合 证据综合
背景情况:
- 评估随机对照试验 (RCT) 和队列研究的证据机构之间的一致性对于可靠的营养证据合成至关重要.
- 之前的研究表明普遍存在共识,但影响分歧的因素需要进一步调查.
研究的目的:
- 在营养证据综合中评估RCT和队列研究之间的效果估计的一致性.
- 识别对影响估计存在分歧的因素.
- 复制之前的元研究研究中的发现.
主要方法:
- 搜索了Medline,Epistemonikos和Cochrane图书馆的营养系统审查,包括RCT和队列研究.
- 评估PI/ECO (人口,干预/暴露,比较,结果) 证据机构之间的相似性.
- 分析了使用二元结果的风险比率 (RRR) 和连续结果的标准化平均差异差异 (DSMD) 的风险比率的分析.
主要成果:
- 包括来自51个系统性审查的82个证据体对.
- 对二进制结果的聚合RRR为1.04 (95%CI 0.991.10);对连续结果的聚合DSMD为-0.09 (95%CI -0.260.09).
- 摄入/暴露类型的差异和PI/ECO差异是分歧的关键驱动因素.
结论:
- 平均而言,RCT和队列研究在营养证据综合中显示了类似的效果估计,证实了先前的发现.
- 不一致和广泛的预测间隔主要与PI/ECO差异有关.
- 需要进一步的研究来探索其他因素,如偏差风险,影响估计分歧.
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