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评估FAPI在肩关节的摄入模式:一项初步研究,与瘤学研究中的FDG摄入量进行比较

Yohji Matsusaka¹, Rudolf A Werner^1,2, Sebastian E Serfling¹

¹Department of Nuclear Medicine and Comprehensive Heart Failure Center (CHFC), Molecular Imaging of the Heart, University Hospital of Würzburg, Oberdürrbacher Str. 6, ZIM House A4, 97080, Würzburg, Germany.

Molecular imaging and biology

|January 4, 2024

概括

Ga-68 FAPI-04 PET/CT成像显示肩关节的吸收增加,特别是关节关节. 这种新型纤维细胞激活蛋白抑制剂 (FAPI) 向显示了比F-18 FDG更高的肩膀吸收率,这表明慢性重塑评估的潜力.

科学领域:

核医学就是核医学.
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

纤维细胞激活蛋白抑制剂 (FAPI) 向PET是一种针对癌症相关纤维细胞的新型成像方式.
已经报告了在肩关节积聚FAPI标记物的偶然发现,但需要进一步描述.
需要进行更大规模的患者队列研究,以充分了解肩关节的FAPI吸收.

研究的目的:

为了研究Ga-68 FAPI-04标记物在肩关节中的吸收率和局部化.
为了比较肩膀中的FAPI吸收与F-18 FDG扫描.
探索FAPI向在评估肩关节状况中的潜力.

主要方法:

包括77名连续接受Ga-68 FAPI-04 PET/CT进行固体瘤诊断的患者.
分析了肩关节的吸收,并与现有的F-18 FDG扫描进行了比较.
进行了在不同肩关节区积累的放射性追踪剂的定量分析.

主要成果:

43.5%的肩关节 (67/154) 显示了Ga-68 FAPI-04吸收的增加.
吸收最为突出的是状关节 (AC) 关节 (37.3%),其次是状关节/下关节 (GH+SA) 关节 (34.3%).
Ga-68 FAPI-04吸收与F-18 FDG吸收有显著的相关性 (r=0.69,p<0.0001),但显示出更高的体内FAP表达 (4.7±3.2与3.6±1.3,p<0.001).

结论:

Ga-68 FAPI-04显示在肩关节,特别是AC关节的焦点积累,吸收率高于F-18 FDG.
需要进行进一步的试验,以调查慢性肩关节重塑的FAPI导向成像.
针对FAPI的成像可能对启动基于PET信号的抗FAP向治疗有影响.

关键词:

骨关节骨关节骨关节骨关节 F-18 化氧化葡萄糖是化氧化葡萄糖.在 FAP FAP 里面.纤维细胞激活抑制剂的激活抑制剂在Ga-68 FAPI-04中使用.骨关节炎是一种骨关节炎.定子发射断层扫描 (PET) 是一种定子发射断层扫描.类风湿性关节炎类风湿性关节炎类风湿性关节炎肩膀肩膀在肩膀上

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