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Updated: Jul 6, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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采用E3结合酶KLHDC2进行小分子向蛋白质降解

Christopher M Hickey1, Katherine M Digianantonio1, Kurt Zimmermann1

  • 1Arvinas, Inc, New Haven, CT, USA.

Nature structural & molecular biology
|January 4, 2024
PubMed
概括

研究人员发现了针对KLHDC2 E3结合酶的新型小分子,使得针对治疗应用的向蛋白降解 (TPD) 成为可能. 这项工作扩展了TPD策略,利用KLHDC2进行基于PROTAC的BET家族和AR蛋白质降解.

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