感染后的情况挑战了SNOT-22的疾病特异性
Mascha E Hildebrandt1, Patrick R Møller2, Alexander W Fjældstad2,3
1Department of Otorhinolaryngology, Head and Neck Surgery, Gødstrup Hospital, University Clinic for Balance, Flavour and Sleep, Hospitalsparken 15, 7400, Herning, Denmark. mhilde@dadlnet.dk.
中鼻结局测试22 (SNOT-22) 评分不能专门识别慢性鼻炎 (CRS). 来自其他原因的嗅觉功能障碍,如COVID-19后,可以产生类似的SNOT-22结果,特别是在睡眠和认知领域.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生活质量评估生活质量评估
- 嗅觉功能障碍 嗅觉功能障碍
背景情况:
- 中鼻结果测试22 (SNOT-22) 被广泛用于评估慢性鼻炎 (CRS) 患者的治疗结果和与健康相关的生活质量 (HRQOL).
- 嗅觉功能障碍 (OD) 与CRS的症状重叠,引发了关于SNOT-22疾病特异性的问题.
- 了解非CRS引起的OD是否会影响SNOT-22得分对于准确的患者评估至关重要.
研究的目的:
- 调查各种后感染原因引起的嗅觉功能障碍 (OD) 是否导致SNOT-22得分与慢性鼻炎 (CRS) 的得分相似.
- 为了确定SNOT-22问卷是否挑战CRS的疾病特异性,当患者出现非CRS相关的OD时.
- 探索特定的SNOT-22症状域在区分多种OD病因学之间的潜力.
主要方法:
- 采用了观察性,回顾性队列研究设计.
- 使用REDCap平台进行前性数据收集.
- 总共分析了460名因COVID-19后的简单或复杂的OD患者,后传染性非COVID-19或CRS.
主要成果:
- 总的SNOT-22得分表明,CRS缺乏疾病特异性.
- 复杂的后感染机制,特别是在COVID-19之后,可能导致SNOT-22得分与CRS患者的得分相似.
- 较高的SNOT-22总分数主要是由"睡眠和认知"症状域内的高分数驱动的.
结论:
- 建议在使用SNOT-22总分作为CRS的唯一查工具时谨慎使用,因为其疾病特异性有限.
- 在SNOT-22中分析个别症状领域对于精确区分嗅觉功能障碍的各种潜在原因至关重要.
- 在四个症状领域中,独特的评分模式可能有助于在临床环境中区分不同的病因.
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