在COVID-19后的患者中,肠道微生物群的改变及其与免疫功能的关联
Jiaojiao Cai1,2, Jingru Xu2, Yan Tan2
1College of Public Health, Chongqing Medical University, Chongqing, 400016, China.
Folia microbiologica
|January 4, 2024
概括
肠道微生物群的改变在2019年冠状病毒 (COVID-19) 幸存者中持续存在,显示有益细菌减少和潜在病原体增加. 这些变化与免疫细胞水平和炎症标志物相关,这表明微生物群调节可能有助于恢复.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物组在免疫系统调节中起着至关重要的作用.
- 了解COVID-19后的长期变化对于患者康复至关重要.
- 失生症与各种炎症状况有关.
研究的目的:
- 为了调查2019年冠状病毒 (COVID-19) 幸存者的肠道微生物组成.
- 探索肠道微生物变化与免疫功能标志物之间的关联.
- 为了确定COVID-19后改变的特定微生物属.
主要方法:
- 高通量16S rRNA测序被用于分析肠道微生物群.
- 在COVID-19幸存者和健康对照者之间比较了微生物群的多样性和丰富性.
- 研究了微生物属和免疫因素 (NK细胞,CD8细胞,IL-8,IL-1β) 之间的相关性.
主要成果:
- 在COVID-19的幸存者中,Subdoligranulum,Haemophilus,Coprococcus,Eubacterium和Lachnospiraceae的水平降低,Hungatella的增加.
- NK细胞与Subdoligranulum负相关;CD8细胞与Subdoligranulum正相关,但与Hungatella负相关.
- 炎症标志物IL-8和IL-1β与特定的微生物种类呈现复杂的相关性,通常与有益细菌和直接与Hungatella相反相关.
结论:
- 在COVID-19幸存者中观察到持续的肠道失调,其特点是有益细菌减少和潜在病原体增加.
- 这些微生物转变与改变的免疫细胞群和炎症概况有关.
- 调节肠道微生物群可能是改善COVID-19患者治疗结果的治疗策略.
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