在前体偏头痛中区域大脑功能指数的动态和一致性变化:静止状态fMRI研究
Xing Xiong1,2, Lingling Dai1,2, Wen Chen1,2
1Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.
The journal of headache and pain
|January 4, 2024
概括
这项研究揭示了前庭偏头痛 (VM) 患者的大脑活动动态的改变,特别是在运动和感官区域. 静脉偏头痛患者表现出大脑活动动态的改变,并具有负担的潜在生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 功能性核磁共振成像 (MRI) 是一种功能性核磁共振成像.
- 大脑活动动态大脑活动动态
背景情况:
- 静脉偏头痛 (VM) 与改变的内在大脑活动 (iBA) 和功能连接性有关.
- 之前的研究集中在静态iBA上,没有探索时间变化.
研究的目的:
- 调查VM患者在间歇期内区域iBA指数的时间动态和一致性.
- 为了确定VM的潜在神经成像生物标志物.
主要方法:
- 休息状态的fMRI被用来比较57名VM患者与88名健康对照 (HC).
- 移动时间窗口分析检查了低频波动 (ALFF) 和区域同质性 (ReHo) 的振幅动态和一致性.
- 部分相关性分析探索了临床数据和fMRI指数之间的关系.
主要成果:
- 脑膜炎患者在运动皮质 (副中心叶片,补充运动区域) 中表现出增加的ALFF和ReHo动态和ALFF-ReHo一致性.
- 在极观察到ReHo动态下降,在小脑,角回形和中回形 (MOG) 中观察到ALFF动态下降.
- 在左侧MOG和的持续时间中,ALFF动态之间发现了正相关性.
结论:
- 变化的时间动态和iBA指数在运动,小脑,尾和尾皮层的一致性表明VM中的多感官处理和前庭控制受到干扰.
- 左侧MOG中的ALFF动态可以作为评估VM中的负担的有价值生物标志物.
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