抗血栓治疗与因COVID‐19住院患者的死亡率之间的关联
Xing Wang1, Wuqian Chen1, Jiulin Guo2
1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Thrombosis journal
|January 4, 2024
概括
口服抗凝剂 (OACs) 在住院COVID-19患者中显著降低了死亡率. 抗血栓治疗还降低了需要机械通风的重症患者的死亡风险.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19与前血栓状况相关,增加了血栓状风险.
- 抗凝剂,特别是口服抗凝剂 (OAC) 在控制COVID-19中的作用仍然存在争议,因为证据有限.
- 这项研究解决了对抗血栓治疗对COVID-19患者结果的影响需要明确的需求.
研究的目的:
- 为了评估抗血栓治疗和住院COVID-19患者的死亡率之间的关联.
- 评估抗血栓治疗对临床结果的影响,包括ICU入院和机械通风.
- 为了研究口服抗凝剂 (OAC) 在这个患者群体中的特定作用.
主要方法:
- 包括成年COVID-19患者在内的回顾性队列研究.
- 倾向性得分匹配 (PSM) 用于控制基线特征.
- 住院死亡率,ICU入院,机械呼吸和急性损伤 (AKI) 是主要和次要结局.
主要成果:
- 与没有抗血栓治疗的患者相比,接受OAC的患者在医院内死亡率显著降低 (aOR:0.46,P=0.017).
- PSM分析证实了OACs降低的死亡风险 (aOR:0.35,P<0.001).
- 抗血栓治疗与需要机械通风的重症COVID-19患者的死亡率降低有关 (aOR:0.54,P=0.022).
结论:
- 口服抗凝剂 (OAC) 与COVID-19患者的医院死亡率降低和机械通风需求有关.
- 抗血栓治疗表明,在需要机械通风的重症COVID-19患者中,住院死亡率显著降低.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
702
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
702
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
526
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
526
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
216
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
216


