在2型糖尿病中,心血管斑块形成的危险因素是2型糖尿病
Jin Chen1, Wenwen Li1, Jingzhu Cao1
1Department of Endocrinology and Metabolism, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Journal of translational medicine
|January 4, 2024
概括
年龄,腰比,糖尿病持续时间,高血压,男性性别和脂蛋白 (a) 是2型糖尿病 (T2DM) 患者动脉样硬化的主要危险因素. 识别这些因素有助于早期预防和治疗策略.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 2型糖尿病 (T2DM) 显著增加了动脉样硬化的风险.
- 在T2DM患者中,动脉样硬化的特定危险因素需要进一步阐明.
- 了解这些因素对于有针对性的预防和治疗至关重要.
研究的目的:
- 在住院T2DM患者中调查与动脉动脉样硬化斑块形成相关的风险因素.
- 确定用于预测T2DM中动脉斑块的关键指标.
- 为早期干预策略提供基础.
主要方法:
- 分析了949名T2DM患者的队列.
- 冠状动脉超声波用于检测动脉样硬化斑块.
- 评估了生物识别数据,血糖,肝/功能,脂质配置文件和小岛功能.
主要成果:
- 确定的独立风险因素包括年龄,腰部与部的比率 (WHR),糖尿病持续时间,高血压,男性性别和脂蛋白 (a) [Lip (a) ].
- 这些因素在T2DM患者中显示出大脑状腺斑块的显著预测价值.
- 使用这些因素的组合模型表明ROC曲线下面的高面积 (0.816).
结论:
- 年龄,WHR,糖尿病持续时间,高血压,男性性别和Lip (a) 是T2DM中动脉斑块的主要风险因素.
- 结合这些指标的多因素方法增强了状腺斑块形成的预测.
- 这些发现支持针对有风险的T2DM患者制定有针对性的预防措施.
相关概念视频
Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Pathophysiology of Diabetes
941
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
941
Diabetes: Symptoms, Diagnosis, and Complications
549
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
549
Diabetes Mellitus: Overview and Type I Subtype
2.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29


