性,激素和脑血管功能:从发育到疾病
Adeline Collignon1, Laurence Dion-Albert1, Caroline Ménard1
1Department of Psychiatry & Neuroscience and CERVO Brain Research Center, Universite Laval, Quebec City, Canada.
Fluids and barriers of the CNS
|January 4, 2024
概括
性激素显著影响大脑血管发育和血脑屏障成熟,影响神经发育障碍,如自闭症谱系障碍 (ASD) 和注意力缺陷/多动症障碍 (ADHD). 了解这些联系可能会揭示新的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 内分泌学 在内分泌学.
背景情况:
- 脑血管发育和神经血管单元组装对于大脑功能至关重要,依赖于血管内皮生长因子 (VEGF) 和Wnt信号传输.
- 性激素可能会影响大脑血管发育,因为性腺轴活动与早期大脑血管形成相吻合.
- 性激素的失调与具有性别特征的神经发育障碍有关,例如自闭症谱系障碍 (ASD) 和注意力缺陷/多动症障碍 (ADHD).
研究的目的:
- 审查性激素对脑血管形成和成熟的影响.
- 探索性腺激素与大脑血管发育和血脑屏障 (BBB) 功能的相互作用.
- 概述VEGF和Wnt信号在ASD和ADHD病变发生过程中的作用.
主要方法:
- 关于性激素,脑血管发育和神经发育障碍的现有研究的文献综述.
- 分析性腺激素对VEGF和Wnt信号通路的调节.
- 检查ASD和ADHD中大脑血流的性别特异性变异.
主要成果:
- 性激素在脑血管发育和BBB成熟中发挥作用.
- 异常的性激素特征与ASD和ADHD有关,这可能解释了患病率和症状的性别差异.
- 阴道激素会影响大脑的血液流动,影响大脑对神经元需求的反应.
结论:
- 性激素是大脑血管发育和功能的关键调节者.
- 了解大脑血管发育中的性别特异性机制可能会导致ASD和ADHD的新治疗方法.
- 进一步研究性腺激素与神经血管路径的相互作用是有必要的.
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