鉴定英格兰C型肝炎病毒产前检测和诊断的错失机会
Matthew Hibbert1,2, Ruth Simmons1,2, Caroline A Sabin2,3
1Blood Safety, Hepatitis, Sexually Transmitted Infections and HIV Division, UK Health Security Agency (UKHSA), London, England.
Journal of viral hepatitis
|January 5, 2024
概括
许多在分娩后被诊断出患有型肝炎病毒 (HCV) 的妇女在产前查期间都错过了. 在怀孕期间普遍选择退出HCV检测可以改善病例发现和消除工作.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 到2030年消除C型肝炎病毒 (HCV) 需要加强英格兰的病例发现策略.
- 产前HCV检测并非普遍提供,但推给有风险因素的女性.
- 识别产前护理中错失的机会对于提高HCV诊断率至关重要.
研究的目的:
- 调查在分娩后被诊断出HCV产前检测的妇女中错过的机会.
- 分析与分娩后延迟HCV诊断相关的人口因素.
- 为了评估这个队列的治疗和肝病严重程度.
主要方法:
- 对活产儿 (2010-2020年) 和HCV诊断 (1995-2021年) 的链接数据分析.
- 确定的妇女在第一次分娩后被诊断出患有HCV.
- 收集关于HCV-RNA测试,治疗和肝脏痕水平的数据.
主要成果:
- 在2010-2020年间分娩的女性中,超过一半 (17,123/32,295) 在分娩后被诊断出患有HCV.
- 在亚洲孟加拉,非洲黑人,中国族裔和出生在非洲的妇女中,产后诊断的几率更高.
- 超过80%的符合条件的妇女与治疗有关,其中很大一部分患有中度肝痕或肝硬化.
结论:
- 许多HCV病例是在分娩后被诊断出来的,这表明错过了产前检测的机会.
- 通过产前服务,针对性地寻找病例对于消除HCV至关重要.
- 应考虑普遍选择退出产前HCV检测,以改善早期检测和治疗.
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